Application of genomics to identify therapeutic targets in recurrent pediatric papillary thyroid carcinoma

Children with papillary thyroid carcinoma (PTC) may relapse despite response to radioactive iodine (RAI). Two children with multiply relapsed PTC underwent whole-genome and transcriptome sequencing. A TPM3-NTRK1 fusion was identified in one tumor, with outlier NTRK1 expression compared to the TCGA t...

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Detalles Bibliográficos
Autores principales: Ronsley, Rebecca, Rassekh, S. Rod, Shen, Yaoqing, Lee, Anna F., Jantzen, Colleen, Halparin, Jessica, Albert, Catherine, Hawkins, Douglas S., Amed, Shazhan, Rothstein, Ralph, Mungall, Andrew J., Dix, David, Blair, Geoffrey, Nadel, Helen, Jones, Steven J.M., Laskin, Janessa, Marra, Marco A., J. Deyell, Rebecca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880264/
https://www.ncbi.nlm.nih.gov/pubmed/29610391
http://dx.doi.org/10.1101/mcs.a002568

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880264/
https://www.ncbi.nlm.nih.gov/pubmed/29610391
http://dx.doi.org/10.1101/mcs.a002568

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