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Application of genomics to identify therapeutic targets in recurrent pediatric papillary thyroid carcinoma
Children with papillary thyroid carcinoma (PTC) may relapse despite response to radioactive iodine (RAI). Two children with multiply relapsed PTC underwent whole-genome and transcriptome sequencing. A TPM3-NTRK1 fusion was identified in one tumor, with outlier NTRK1 expression compared to the TCGA t...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880264/ https://www.ncbi.nlm.nih.gov/pubmed/29610391 http://dx.doi.org/10.1101/mcs.a002568 |
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author | Ronsley, Rebecca Rassekh, S. Rod Shen, Yaoqing Lee, Anna F. Jantzen, Colleen Halparin, Jessica Albert, Catherine Hawkins, Douglas S. Amed, Shazhan Rothstein, Ralph Mungall, Andrew J. Dix, David Blair, Geoffrey Nadel, Helen Jones, Steven J.M. Laskin, Janessa Marra, Marco A. J. Deyell, Rebecca |
author_facet | Ronsley, Rebecca Rassekh, S. Rod Shen, Yaoqing Lee, Anna F. Jantzen, Colleen Halparin, Jessica Albert, Catherine Hawkins, Douglas S. Amed, Shazhan Rothstein, Ralph Mungall, Andrew J. Dix, David Blair, Geoffrey Nadel, Helen Jones, Steven J.M. Laskin, Janessa Marra, Marco A. J. Deyell, Rebecca |
author_sort | Ronsley, Rebecca |
collection | PubMed |
description | Children with papillary thyroid carcinoma (PTC) may relapse despite response to radioactive iodine (RAI). Two children with multiply relapsed PTC underwent whole-genome and transcriptome sequencing. A TPM3-NTRK1 fusion was identified in one tumor, with outlier NTRK1 expression compared to the TCGA thyroid cancer compendium and to Illumina BodyMap normal thyroid. This patient demonstrated resolution of multiple pulmonary nodules without toxicity on oral TRK inhibitor therapy. A RET fusion was identified in the second tumor, another potentially actionable finding. Identification of oncogenic drivers in recurrent pediatric PTC may facilitate targeted therapy while avoiding repeated RAI. |
format | Online Article Text |
id | pubmed-5880264 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-58802642018-04-13 Application of genomics to identify therapeutic targets in recurrent pediatric papillary thyroid carcinoma Ronsley, Rebecca Rassekh, S. Rod Shen, Yaoqing Lee, Anna F. Jantzen, Colleen Halparin, Jessica Albert, Catherine Hawkins, Douglas S. Amed, Shazhan Rothstein, Ralph Mungall, Andrew J. Dix, David Blair, Geoffrey Nadel, Helen Jones, Steven J.M. Laskin, Janessa Marra, Marco A. J. Deyell, Rebecca Cold Spring Harb Mol Case Stud Research Report Children with papillary thyroid carcinoma (PTC) may relapse despite response to radioactive iodine (RAI). Two children with multiply relapsed PTC underwent whole-genome and transcriptome sequencing. A TPM3-NTRK1 fusion was identified in one tumor, with outlier NTRK1 expression compared to the TCGA thyroid cancer compendium and to Illumina BodyMap normal thyroid. This patient demonstrated resolution of multiple pulmonary nodules without toxicity on oral TRK inhibitor therapy. A RET fusion was identified in the second tumor, another potentially actionable finding. Identification of oncogenic drivers in recurrent pediatric PTC may facilitate targeted therapy while avoiding repeated RAI. Cold Spring Harbor Laboratory Press 2018-04 /pmc/articles/PMC5880264/ /pubmed/29610391 http://dx.doi.org/10.1101/mcs.a002568 Text en © 2018 Ronsley et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/) , which permits reuse and redistribution, except for commercial purposes, provided that the original author and source are credited. |
spellingShingle | Research Report Ronsley, Rebecca Rassekh, S. Rod Shen, Yaoqing Lee, Anna F. Jantzen, Colleen Halparin, Jessica Albert, Catherine Hawkins, Douglas S. Amed, Shazhan Rothstein, Ralph Mungall, Andrew J. Dix, David Blair, Geoffrey Nadel, Helen Jones, Steven J.M. Laskin, Janessa Marra, Marco A. J. Deyell, Rebecca Application of genomics to identify therapeutic targets in recurrent pediatric papillary thyroid carcinoma |
title | Application of genomics to identify therapeutic targets in recurrent pediatric papillary thyroid carcinoma |
title_full | Application of genomics to identify therapeutic targets in recurrent pediatric papillary thyroid carcinoma |
title_fullStr | Application of genomics to identify therapeutic targets in recurrent pediatric papillary thyroid carcinoma |
title_full_unstemmed | Application of genomics to identify therapeutic targets in recurrent pediatric papillary thyroid carcinoma |
title_short | Application of genomics to identify therapeutic targets in recurrent pediatric papillary thyroid carcinoma |
title_sort | application of genomics to identify therapeutic targets in recurrent pediatric papillary thyroid carcinoma |
topic | Research Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880264/ https://www.ncbi.nlm.nih.gov/pubmed/29610391 http://dx.doi.org/10.1101/mcs.a002568 |
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