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Application of genomics to identify therapeutic targets in recurrent pediatric papillary thyroid carcinoma

Children with papillary thyroid carcinoma (PTC) may relapse despite response to radioactive iodine (RAI). Two children with multiply relapsed PTC underwent whole-genome and transcriptome sequencing. A TPM3-NTRK1 fusion was identified in one tumor, with outlier NTRK1 expression compared to the TCGA t...

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Autores principales: Ronsley, Rebecca, Rassekh, S. Rod, Shen, Yaoqing, Lee, Anna F., Jantzen, Colleen, Halparin, Jessica, Albert, Catherine, Hawkins, Douglas S., Amed, Shazhan, Rothstein, Ralph, Mungall, Andrew J., Dix, David, Blair, Geoffrey, Nadel, Helen, Jones, Steven J.M., Laskin, Janessa, Marra, Marco A., J. Deyell, Rebecca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880264/
https://www.ncbi.nlm.nih.gov/pubmed/29610391
http://dx.doi.org/10.1101/mcs.a002568
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author Ronsley, Rebecca
Rassekh, S. Rod
Shen, Yaoqing
Lee, Anna F.
Jantzen, Colleen
Halparin, Jessica
Albert, Catherine
Hawkins, Douglas S.
Amed, Shazhan
Rothstein, Ralph
Mungall, Andrew J.
Dix, David
Blair, Geoffrey
Nadel, Helen
Jones, Steven J.M.
Laskin, Janessa
Marra, Marco A.
J. Deyell, Rebecca
author_facet Ronsley, Rebecca
Rassekh, S. Rod
Shen, Yaoqing
Lee, Anna F.
Jantzen, Colleen
Halparin, Jessica
Albert, Catherine
Hawkins, Douglas S.
Amed, Shazhan
Rothstein, Ralph
Mungall, Andrew J.
Dix, David
Blair, Geoffrey
Nadel, Helen
Jones, Steven J.M.
Laskin, Janessa
Marra, Marco A.
J. Deyell, Rebecca
author_sort Ronsley, Rebecca
collection PubMed
description Children with papillary thyroid carcinoma (PTC) may relapse despite response to radioactive iodine (RAI). Two children with multiply relapsed PTC underwent whole-genome and transcriptome sequencing. A TPM3-NTRK1 fusion was identified in one tumor, with outlier NTRK1 expression compared to the TCGA thyroid cancer compendium and to Illumina BodyMap normal thyroid. This patient demonstrated resolution of multiple pulmonary nodules without toxicity on oral TRK inhibitor therapy. A RET fusion was identified in the second tumor, another potentially actionable finding. Identification of oncogenic drivers in recurrent pediatric PTC may facilitate targeted therapy while avoiding repeated RAI.
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spelling pubmed-58802642018-04-13 Application of genomics to identify therapeutic targets in recurrent pediatric papillary thyroid carcinoma Ronsley, Rebecca Rassekh, S. Rod Shen, Yaoqing Lee, Anna F. Jantzen, Colleen Halparin, Jessica Albert, Catherine Hawkins, Douglas S. Amed, Shazhan Rothstein, Ralph Mungall, Andrew J. Dix, David Blair, Geoffrey Nadel, Helen Jones, Steven J.M. Laskin, Janessa Marra, Marco A. J. Deyell, Rebecca Cold Spring Harb Mol Case Stud Research Report Children with papillary thyroid carcinoma (PTC) may relapse despite response to radioactive iodine (RAI). Two children with multiply relapsed PTC underwent whole-genome and transcriptome sequencing. A TPM3-NTRK1 fusion was identified in one tumor, with outlier NTRK1 expression compared to the TCGA thyroid cancer compendium and to Illumina BodyMap normal thyroid. This patient demonstrated resolution of multiple pulmonary nodules without toxicity on oral TRK inhibitor therapy. A RET fusion was identified in the second tumor, another potentially actionable finding. Identification of oncogenic drivers in recurrent pediatric PTC may facilitate targeted therapy while avoiding repeated RAI. Cold Spring Harbor Laboratory Press 2018-04 /pmc/articles/PMC5880264/ /pubmed/29610391 http://dx.doi.org/10.1101/mcs.a002568 Text en © 2018 Ronsley et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/) , which permits reuse and redistribution, except for commercial purposes, provided that the original author and source are credited.
spellingShingle Research Report
Ronsley, Rebecca
Rassekh, S. Rod
Shen, Yaoqing
Lee, Anna F.
Jantzen, Colleen
Halparin, Jessica
Albert, Catherine
Hawkins, Douglas S.
Amed, Shazhan
Rothstein, Ralph
Mungall, Andrew J.
Dix, David
Blair, Geoffrey
Nadel, Helen
Jones, Steven J.M.
Laskin, Janessa
Marra, Marco A.
J. Deyell, Rebecca
Application of genomics to identify therapeutic targets in recurrent pediatric papillary thyroid carcinoma
title Application of genomics to identify therapeutic targets in recurrent pediatric papillary thyroid carcinoma
title_full Application of genomics to identify therapeutic targets in recurrent pediatric papillary thyroid carcinoma
title_fullStr Application of genomics to identify therapeutic targets in recurrent pediatric papillary thyroid carcinoma
title_full_unstemmed Application of genomics to identify therapeutic targets in recurrent pediatric papillary thyroid carcinoma
title_short Application of genomics to identify therapeutic targets in recurrent pediatric papillary thyroid carcinoma
title_sort application of genomics to identify therapeutic targets in recurrent pediatric papillary thyroid carcinoma
topic Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880264/
https://www.ncbi.nlm.nih.gov/pubmed/29610391
http://dx.doi.org/10.1101/mcs.a002568
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