Ozanimod (RPC1063), a selective S1P(R1) and S1P(R5) modulator, reduces chronic inflammation and alleviates kidney pathology in murine systemic lupus erythematosus

Ozanimod (RPC1063) is a specific and potent small molecule modulator of the sphingosine 1-phosphate receptor 1 (S1P(R1)) and receptor 5 (S1P(R5)), which has shown therapeutic benefit in clinical trials of relapsing multiple sclerosis and ulcerative colitis. Ozanimod and its active metabolite, RP-101...

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Detalles Bibliográficos
Autores principales: Taylor Meadows, Kristen R., Steinberg, Marcos W., Clemons, Bryan, Stokes, Matthew E., Opiteck, Gregory J., Peach, Robert, Scott, Fiona L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880347/
https://www.ncbi.nlm.nih.gov/pubmed/29608575
http://dx.doi.org/10.1371/journal.pone.0193236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880347/
https://www.ncbi.nlm.nih.gov/pubmed/29608575
http://dx.doi.org/10.1371/journal.pone.0193236

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