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Ozanimod (RPC1063), a selective S1P(R1) and S1P(R5) modulator, reduces chronic inflammation and alleviates kidney pathology in murine systemic lupus erythematosus
Ozanimod (RPC1063) is a specific and potent small molecule modulator of the sphingosine 1-phosphate receptor 1 (S1P(R1)) and receptor 5 (S1P(R5)), which has shown therapeutic benefit in clinical trials of relapsing multiple sclerosis and ulcerative colitis. Ozanimod and its active metabolite, RP-101...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880347/ https://www.ncbi.nlm.nih.gov/pubmed/29608575 http://dx.doi.org/10.1371/journal.pone.0193236 |