The beta secretase BACE1 regulates the expression of insulin receptor in the liver

Insulin receptor (IR) plays a key role in the control of glucose homeostasis; however, the regulation of its cellular expression remains poorly understood. Here we show that the amount of biologically active IR is regulated by the cleavage of its ectodomain, by the β-site amyloid precursor protein c...

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Detalles Bibliográficos
Autores principales: Meakin, Paul J., Mezzapesa, Anna, Benabou, Eva, Haas, Mary E., Bonardo, Bernadette, Grino, Michel, Brunel, Jean-Michel, Desbois-Mouthon, Christèle, Biddinger, Sudha B., Govers, Roland, Ashford, Michael L. J., Peiretti, Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880807/
https://www.ncbi.nlm.nih.gov/pubmed/29610518
http://dx.doi.org/10.1038/s41467-018-03755-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880807/
https://www.ncbi.nlm.nih.gov/pubmed/29610518
http://dx.doi.org/10.1038/s41467-018-03755-2

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