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Sumoylation Protects Against β-Synuclein Toxicity in Yeast
Aggregation of α-synuclein (αSyn) plays a central role in the pathogenesis of Parkinson’s disease (PD). The budding yeast Saccharomyces cerevisiae serves as reference cell to study the interplay between αSyn misfolding, cytotoxicity and post-translational modifications (PTMs). The synuclein family i...
Autores principales: | Popova, Blagovesta, Kleinknecht, Alexandra, Arendarski, Patricia, Mischke, Jasmin, Wang, Dan, Braus, Gerhard H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880895/ https://www.ncbi.nlm.nih.gov/pubmed/29636661 http://dx.doi.org/10.3389/fnmol.2018.00094 |
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