Genetic defects in SAPK signalling, chromatin regulation, vesicle transport and CoA-related lipid metabolism are rescued by rapamycin in fission yeast

Rapamycin inhibits TOR (target of rapamycin) kinase, and is being used clinically to treat various diseases ranging from cancers to fibrodysplasia ossificans progressiva. To understand rapamycin mechanisms of action more comprehensively, 1014 temperature-sensitive (ts) fission yeast (Schizosaccharom...

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Detalles Bibliográficos
Autores principales: Sajiki, Kenichi, Tahara, Yuria, Villar-Briones, Alejandro, Pluskal, Tomáš, Teruya, Takayuki, Mori, Ayaka, Hatanaka, Mitsuko, Ebe, Masahiro, Nakamura, Takahiro, Aoki, Keita, Nakaseko, Yukinobu, Yanagida, Mitsuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881033/
https://www.ncbi.nlm.nih.gov/pubmed/29593117
http://dx.doi.org/10.1098/rsob.170261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881033/
https://www.ncbi.nlm.nih.gov/pubmed/29593117
http://dx.doi.org/10.1098/rsob.170261

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