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Hypoxia Upregulates Mitotic Cyclins Which Contribute to the Multipotency of Human Mesenchymal Stem Cells by Expanding Proliferation Lifespan

Hypoxic culture is widely recognized as a method to efficiently expand human mesenchymal stem cells (MSCs) without loss of stem cell properties. However, the molecular basis of how hypoxia priming benefits MSC expansion remains unclear. In this report, our systemic quantitative proteomic and RT-PCR...

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Detalles Bibliográficos
Autores principales: Lee, Janet, Kim, Hyun-Soo, Kim, Su-Min, Kim, Dong-Ik, Lee, Chang-Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881094/
https://www.ncbi.nlm.nih.gov/pubmed/29463071
http://dx.doi.org/10.14348/molcells.2018.2231