Cargando…
OASL1 Traps Viral RNAs in Stress Granules to Promote Antiviral Responses
Oligoadenylate synthetase (OAS) protein family is the major interferon (IFN)-stimulated genes responsible for the activation of RNase L pathway upon viral infection. OAS-like (OASL) is also required for inhibition of viral growth in human cells, but the loss of one of its mouse homolog, OASL1, cause...
Autores principales: | Kang, Ji-Seon, Hwang, Yune-Sahng, Kim, Lark Kyun, Lee, Sujung, Lee, Wook-Bin, Kim-Ha, Jeongsil, Kim, Young-Joon |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Molecular and Cellular Biology
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881095/ https://www.ncbi.nlm.nih.gov/pubmed/29463066 http://dx.doi.org/10.14348/molcells.2018.2293 |
Ejemplares similares
-
Oligoadenylate synthase-like (OASL) proteins: dual functions and associations with diseases
por: Choi, Un Yung, et al.
Publicado: (2015) -
Negative Regulation of Type I IFN Expression by OASL1 Permits Chronic Viral Infection and CD8(+) T-Cell Exhaustion
por: Lee, Myeong Sup, et al.
Publicado: (2013) -
Down-Regulation of NF-κB Target Genes by the AP-1 and STAT Complex during the Innate Immune Response in Drosophila
por: Kim, Lark Kyun, et al.
Publicado: (2007) -
OASL1 deficiency promotes antiviral protection against genital herpes simplex virus type 2 infection by enhancing type I interferon production
por: Oh, Ji Eun, et al.
Publicado: (2016) -
OASL1-Mediated Inhibition of Type I IFN Reduces Influenza A Infection-Induced Airway Inflammation by Regulating ILC2s
por: Chang, Yuna, et al.
Publicado: (2021)