Application of Physiologically Based Pharmacokinetic (PBPK) Modeling Within a Bayesian Framework to Identify Poor Metabolizers of Efavirenz (PM), Using a Test Dose of Efavirenz

Poor metabolisers of CYP2B6 (PM) require a lower dose of efavirenz because of serious adverse reactions resulting from the higher plasma concentrations associated with a standard dose. Treatment discontinuation is a common consequence in patients experiencing these adverse reactions. Such patients b...

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Detalles Bibliográficos
Autores principales: Chetty, Manoranjenni, Cain, Theresa, Wedagedera, Janak, Rostami-Hodjegan, Amin, Jamei, Masoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881162/
https://www.ncbi.nlm.nih.gov/pubmed/29636682
http://dx.doi.org/10.3389/fphar.2018.00247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881162/
https://www.ncbi.nlm.nih.gov/pubmed/29636682
http://dx.doi.org/10.3389/fphar.2018.00247

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