Mutant IDH1 gliomas downregulate phosphocholine and phosphoethanolamine synthesis in a 2-hydroxyglutarate-dependent manner

BACKGROUND: Magnetic resonance spectroscopy (MRS) studies have identified elevated levels of the phospholipid precursor phosphocholine (PC) and phosphoethanolamine (PE) as metabolic hallmarks of cancer. Unusually, however, PC and PE levels are reduced in mutant isocitrate dehydrogenase 1 (IDHmut) gl...

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Detalles Bibliográficos
Autores principales: Viswanath, Pavithra, Radoul, Marina, Izquierdo-Garcia, Jose Luis, Luchman, Hema Artee, Gregory Cairncross, J., Pieper, Russell O., Phillips, Joanna J., Ronen, Sabrina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881177/
https://www.ncbi.nlm.nih.gov/pubmed/29619216
http://dx.doi.org/10.1186/s40170-018-0178-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881177/
https://www.ncbi.nlm.nih.gov/pubmed/29619216
http://dx.doi.org/10.1186/s40170-018-0178-3

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