Molecular Defects in Cardiac Myofilament Ca(2+)-Regulation Due to Cardiomyopathy-Linked Mutations Can Be Reversed by Small Molecules Binding to Troponin

The inherited cardiomyopathies, hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) are relatively common, potentially life-threatening and currently untreatable. Mutations are often in the contractile proteins of cardiac muscle and cause abnormal Ca(2+) regulation via troponin. HCM i...

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Detalles Bibliográficos
Autores principales: Sheehan, Alice, Messer, Andrew E., Papadaki, Maria, Choudhry, Afnan, Kren, Vladimír, Biedermann, David, Blagg, Brian, Khandelwal, Anuj, Marston, Steven B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881522/
https://www.ncbi.nlm.nih.gov/pubmed/29636697
http://dx.doi.org/10.3389/fphys.2018.00243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881522/
https://www.ncbi.nlm.nih.gov/pubmed/29636697
http://dx.doi.org/10.3389/fphys.2018.00243

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