Crystal structures of FMN‐bound and FMN‐free forms of dihydroorotate dehydrogenase from Trypanosoma brucei

Dihydroorotate dehydrogenase (DHODH) is a flavin‐binding enzyme essential for pyrimidine biosynthesis, which converts dihydroorotate to orotate. Three‐dimensional structures of cytosolic DHODH of parasitic protozoa are of interest in drug discovery for neglected tropical diseases, especially because...

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Detalles Bibliográficos
Autores principales: Kubota, Tomomi, Tani, Osamu, Yamaguchi, Tomohiko, Namatame, Ichiji, Sakashita, Hitoshi, Furukawa, Koji, Yamasaki, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881531/
https://www.ncbi.nlm.nih.gov/pubmed/29632820
http://dx.doi.org/10.1002/2211-5463.12403

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881531/
https://www.ncbi.nlm.nih.gov/pubmed/29632820
http://dx.doi.org/10.1002/2211-5463.12403

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