ADAM17 is essential for ectodomain shedding of the EGF‐receptor ligand amphiregulin

The epidermal growth factor (EGF)‐receptor ligand amphiregulin (AREG) is a potent growth factor implicated in proliferative skin diseases and in primary and metastatic epithelial cancers. AREG, synthesized as a propeptide, requires conversion to an active peptide by metalloproteases by a process kno...

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Detalles Bibliográficos
Autores principales: Hosur, Vishnu, Farley, Michelle L., Burzenski, Lisa M., Shultz, Leonard D., Wiles, Michael V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881543/
https://www.ncbi.nlm.nih.gov/pubmed/29632822
http://dx.doi.org/10.1002/2211-5463.12407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881543/
https://www.ncbi.nlm.nih.gov/pubmed/29632822
http://dx.doi.org/10.1002/2211-5463.12407

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