Inhibition of DNA methyltransferase leads to increased genomic 5‐hydroxymethylcytosine levels in hematopoietic cells

5‐Hydroxymethylcytosine (5hmC) is produced from 5‐methylcytosine (5mC) by Ten‐eleven translocation (TET) dioxygenases. The epigenetic modification 5hmC has crucial roles in both cellular development and differentiation. The 5hmC level is particularly high in the brain. While 5mC is generally associa...

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Detalles Bibliográficos
Autores principales: Vető, Borbála, Szabó, Pál, Bacquet, Caroline, Apró, Anna, Hathy, Edit, Kiss, Judit, Réthelyi, János M., Szeri, Flóra, Szüts, Dávid, Arányi, Tamás
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881552/
https://www.ncbi.nlm.nih.gov/pubmed/29632811
http://dx.doi.org/10.1002/2211-5463.12392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881552/
https://www.ncbi.nlm.nih.gov/pubmed/29632811
http://dx.doi.org/10.1002/2211-5463.12392

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