Cargando…

Two distinct conformational states define the interaction of human RAD51‐ATP with single‐stranded DNA

An essential mechanism for repairing DNA double‐strand breaks is homologous recombination (HR). One of its core catalysts is human RAD51 (hRAD51), which assembles as a helical nucleoprotein filament on single‐stranded DNA, promoting DNA‐strand exchange. Here, we study the interaction of hRAD51 with...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brouwer, Ineke, Moschetti, Tommaso, Candelli, Andrea, Garcin, Edwige B, Modesti, Mauro, Pellegrini, Luca, Wuite, Gijs JL, Peterman, Erwin JG
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881629/ https://www.ncbi.nlm.nih.gov/pubmed/29507080 http://dx.doi.org/10.15252/embj.201798162

Ejemplares similares

Human RAD52 Captures and Holds DNA Strands, Increases DNA Flexibility, and Prevents Melting of Duplex DNA: Implications for DNA Recombination
por: Brouwer, Ineke, et al.
Publicado: (2017)

Counting RAD51 proteins disassembling from nucleoprotein filaments under tension
por: van Mameren, Joost, et al.
Publicado: (2008)

Viscoelastic properties of vimentin originate from nonequilibrium conformational changes
por: Block, Johanna, et al.
Publicado: (2018)

Sequential role of RAD51 paralog complexes in replication fork remodeling and restart
por: Berti, Matteo, et al.
Publicado: (2020)

Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells
por: Garcin, Edwige B., et al.
Publicado: (2019)

Single-molecule observation of DNA compaction by meiotic protein SYCP3
por: Syrjänen, Johanna L, et al.
Publicado: (2017)

ATP half‐sites in RadA and RAD51 recombinases bind nucleotides
por: Marsh, May E., et al.
Publicado: (2016)

TODRA, a lncRNA at the RAD51 Locus, Is Oppositely Regulated to RAD51, and Enhances RAD51-Dependent DSB (Double Strand Break) Repair
por: Gazy, Inbal, et al.
Publicado: (2015)

Human Rad51 filaments on double- and single-stranded DNA: correlating regular and irregular forms with recombination function
por: Ristic, Dejan, et al.
Publicado: (2005)

RAD51 and RAD51B Play Diverse Roles in the Repair of DNA Double Strand Breaks in Physcomitrium patens
por: Angelis, Karel J., et al.
Publicado: (2023)

ATP-dependent nucleosome unwrapping catalyzed by human RAD51
por: North, Justin A., et al.
Publicado: (2013)

Imaging unlabeled proteins on DNA with super-resolution
por: Meijering, Anna E C, et al.
Publicado: (2020)

RADX condenses single-stranded DNA to antagonize RAD51 loading
por: Zhang, Hongshan, et al.
Publicado: (2020)

A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death
por: Scott, Duncan E., et al.
Publicado: (2021)

Roles of XRCC2, RAD51B and RAD51D in RAD51-Independent SSA Recombination
por: Serra, Heïdi, et al.
Publicado: (2013)

Analysis of the impact of the absence of RAD51 strand exchange activity in Arabidopsis meiosis
por: Singh, Gunjita, et al.
Publicado: (2017)

Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor
por: Greenhough, Luke A., et al.
Publicado: (2023)

A region of human BRCA2 containing multiple BRC repeats promotes RAD51-mediated strand exchange
por: Shivji, Mahmud K. K., et al.
Publicado: (2006)

Homologous Pairing Activities of Two Rice RAD51 Proteins, RAD51A1 and RAD51A2
por: Morozumi, Yuichi, et al.
Publicado: (2013)

Conformational flexibility and oligomerization of BRCA2 regions induced by RAD51 interaction
por: Sidhu, Arshdeep, et al.
Publicado: (2020)

Identification of a novel human Rad51 variant that promotes DNA strand exchange
por: Park, Jung-Young, et al.
Publicado: (2008)

GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination
por: Takizawa, Yoshimasa, et al.
Publicado: (2010)

OsRAD51C is essential for double-strand break repair in rice meiosis
por: Tang, Ding, et al.
Publicado: (2014)

Real-time assembly and disassembly of human RAD51 filaments on individual DNA molecules
por: van der Heijden, Thijn, et al.
Publicado: (2007)

Rad51 paralogs Rad55-Rad57 balance the anti-recombinase Srs2 in Rad51 filament formation
por: Liu, Jie, et al.
Publicado: (2011)

The RecQ helicase Sgs1 drives ATP-dependent disruption of Rad51 filaments
por: Crickard, J Brooks, et al.
Publicado: (2019)

See me, feel me: methods to concurrently visualize and manipulate single DNA molecules and associated proteins
por: van Mameren, Joost, et al.
Publicado: (2008)

Unravelling the structural plasticity of stretched DNA under torsional constraint
por: King, Graeme A., et al.
Publicado: (2016)

Contributions of the RAD51 N-terminal domain to BRCA2-RAD51 interaction
por: Subramanyam, Shyamal, et al.
Publicado: (2013)

RAD51AP1 mediates RAD51 activity through nucleosome interaction
por: Pires, Elena, et al.
Publicado: (2021)

Hot on RAD51C: structure and functions of RAD51C‐XRCC3
por: Szakal, Barnabas, et al.
Publicado: (2023)

Engineering Archeal Surrogate Systems for the Development of Protein–Protein Interaction Inhibitors against Human RAD51
por: Moschetti, Tommaso, et al.
Publicado: (2016)

Human PSF binds to RAD51 and modulates its homologous-pairing and strand-exchange activities
por: Morozumi, Yuichi, et al.
Publicado: (2009)

DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange
por: Ishida, Takako, et al.
Publicado: (2009)

The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway
por: Rosenbaum, Joel C., et al.
Publicado: (2019)

A Rad51-independent pathway promotes single-strand template repair in gene editing
por: Gallagher, Danielle N., et al.
Publicado: (2020)

The Shu complex interacts with Rad51 through the Rad51 paralogues Rad55–Rad57 to mediate error-free recombination
por: Godin, Stephen, et al.
Publicado: (2013)

Arabidopsis RAD51, RAD51C and XRCC3 proteins form a complex and facilitate RAD51 localization on chromosomes for meiotic recombination
por: Su, Hang, et al.
Publicado: (2017)

Structural basis for stabilisation of the RAD51 nucleoprotein filament by BRCA2
por: Appleby, Robert, et al.
Publicado: (2023)

Rad51 and Rad54 ATPase activities are both required to modulate Rad51-dsDNA filament dynamics
por: Li, Xuan, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_mdiimungeueeng3dsvjstodoul