PEDF protects cardiomyocytes by promoting FUNDC1-mediated mitophagy via PEDF-R under hypoxic condition

Pigment epithelial-derived factor (PEDF) is known to exert diverse physiological activities. Previous studies suggest that hypoxia could induce mitophagy. Astoundingly, under hypoxic condition, we found that PEDF decreased the mitochondrial density of cardiomyocytes. In this study, we evaluated whet...

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Detalles Bibliográficos
Autores principales: Li, Yufeng, Liu, Zhiwei, Zhang, Yiqian, Zhao, Qixiang, Wang, Xiaoyu, Lu, Peng, Zhang, Hao, Wang, Zhu, Dong, Hongyan, Zhang, Zhongming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881750/
https://www.ncbi.nlm.nih.gov/pubmed/29512692
http://dx.doi.org/10.3892/ijmm.2018.3536

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881750/
https://www.ncbi.nlm.nih.gov/pubmed/29512692
http://dx.doi.org/10.3892/ijmm.2018.3536

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