Cargando…

PEDF protects cardiomyocytes by promoting FUNDC1-mediated mitophagy via PEDF-R under hypoxic condition

Pigment epithelial-derived factor (PEDF) is known to exert diverse physiological activities. Previous studies suggest that hypoxia could induce mitophagy. Astoundingly, under hypoxic condition, we found that PEDF decreased the mitochondrial density of cardiomyocytes. In this study, we evaluated whet...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Yufeng, Liu, Zhiwei, Zhang, Yiqian, Zhao, Qixiang, Wang, Xiaoyu, Lu, Peng, Zhang, Hao, Wang, Zhu, Dong, Hongyan, Zhang, Zhongming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881750/ https://www.ncbi.nlm.nih.gov/pubmed/29512692 http://dx.doi.org/10.3892/ijmm.2018.3536

Ejemplares similares

PEDF regulates lipid metabolism and reduces apoptosis in hypoxic H9c2 cells by inducing autophagy related 5-mediated autophagy via PEDF-R
por: Zhang, Yiqian, et al.
Publicado: (2018)

PEDF Inhibits the Activation of NLRP3 Inflammasome in Hypoxia Cardiomyocytes through PEDF Receptor/Phospholipase A2
por: Zhou, Zhongxin, et al.
Publicado: (2016)

PEDF improves cardiac function in rats subjected to myocardial ischemia/reperfusion injury by inhibiting ROS generation via PEDF-R
por: Zhao, Qixiang, et al.
Publicado: (2018)

PKCα replaces AMPK to regulate mitophagy: Another PEDF role on ischaemic cardioprotection
por: Miao, Haoran, et al.
Publicado: (2018)

Pigment Epithelium‐Derived Factor (PEDF) Improves Ischemic Cardiac Functional Reserve Through Decreasing Hypoxic Cardiomyocyte Contractility Through PEDF Receptor (PEDF‐R)
por: Lu, Peng, et al.
Publicado: (2016)

PEDF and PEDF-derived peptide 44mer protect cardiomyocytes against hypoxia-induced apoptosis and necroptosis via anti-oxidative effect
por: Gao, Xiao, et al.
Publicado: (2014)

PEDF and PEDF-derived peptide 44mer stimulate cardiac triglyceride degradation via ATGL
por: Zhang, Hao, et al.
Publicado: (2015)

PEDF decreases cardiomyocyte edema during oxygen-glucose deprivation and recovery via inhibiting lactate accumulation and expression of AQP1
por: Huang, Bing, et al.
Publicado: (2019)

Pigment Epithelium-Derived Factor (PEDF) Protects Osteoblastic Cell Line from Glucocorticoid-Induced Apoptosis via PEDF-R
por: Yao, Shengcheng, et al.
Publicado: (2016)

Pressure-Induced Alterations in PEDF and PEDF-R Expression: Implications for Neuroprotective Signaling in Glaucoma
por: Lee, Sean J, et al.
Publicado: (2015)

PEDF is an antifibrosis factor that inhibits the activation of fibroblasts in a bleomycin-induced pulmonary fibrosis rat model
por: Qin, Xichun, et al.
Publicado: (2022)

Pigment epithelium derived factor (PEDF) prevents methyl methacrylate monomer-induced cytotoxicity in H9c2 cells
por: Xin, Li, et al.
Publicado: (2017)

The Role of PEDF in Reproductive Aging of the Ovary †
por: Nemerovsky, Luba, et al.
Publicado: (2022)

PEDF in Diabetic Retinopathy: A Protective Effect of Oxidative Stress
por: Zhu, Xiao-feng, et al.
Publicado: (2012)

Mesenchymal stem cells overexpressing PEDF decrease the angiogenesis of gliomas
por: Wang, Qiaoshu, et al.
Publicado: (2013)

The Emerging Role of PEDF in Stem Cell Biology
por: Elahy, Mina, et al.
Publicado: (2012)

PEDF – A Noninhibitory Serpin with Neurotrophic Activity
por: Minkevich, N.I., et al.
Publicado: (2010)

PEDF Protects Endothelial Barrier Integrity during Acute Myocardial Infarction via 67LR
por: Liang, Jingtian, et al.
Publicado: (2023)

PEDF Improves Cardiac Function in Rats with Acute Myocardial Infarction via Inhibiting Vascular Permeability and Cardiomyocyte Apoptosis
por: Zhang, Hao, et al.
Publicado: (2015)

Codon Preference Optimization Increases Heterologous PEDF Expression
por: Gvritishvili, Anzor G., et al.
Publicado: (2010)

The contrary intracellular and extracellular functions of PEDF in HCC development
por: Li, Cen, et al.
Publicado: (2019)

PEDF Deletion Induces Senescence and Defects in Phagocytosis in the RPE
por: Rebustini, Ivan T., et al.
Publicado: (2022)

Receptors that bind to PEDF and their therapeutic roles in retinal diseases
por: Xu, Manhong, et al.
Publicado: (2023)

Enhanced therapeutic effect of PEDF-loaded mesenchymal stem cell-derived small extracellular vesicles against oxygen-induced retinopathy through increased stability and penetrability of PEDF
por: Fan, Ruiyan, et al.
Publicado: (2023)

PEDF Gene Deletion Disrupts Corneal Innervation and Ocular Surface Function
por: Shang, Zhenying, et al.
Publicado: (2021)

PEDF Is Associated with the Termination of Chondrocyte Phenotype and Catabolism of Cartilage Tissue
por: Klinger, P., et al.
Publicado: (2017)

PEDF inhibits pancreatic tumorigenesis by attenuating the fibro-inflammatory reaction
por: Principe, Daniel R., et al.
Publicado: (2016)

GLUT1 activity contributes to the impairment of PEDF secretion by the RPE
por: Calado, Sofia M., et al.
Publicado: (2016)

PEDF inhibits lymphatic metastasis of nasopharyngeal carcinoma as a new lymphangiogenesis inhibitor
por: Luo, Chuanghua, et al.
Publicado: (2021)

PEDF and its roles in physiological and pathological conditions: implication in diabetic and hypoxia-induced angiogenic diseases
por: He, Xuemin, et al.
Publicado: (2015)

PEDF inhibits non-small cell lung cancer proliferation by suppressing autophagy through downregulation of AMPK-ULK1 signaling
por: Miao, Haoran, et al.
Publicado: (2022)

PEDF Regulates Vascular Permeability by a γ-Secretase-Mediated Pathway
por: Cai, Jun, et al.
Publicado: (2011)

Pigment Epithelium-Derived Factor (PEDF) as a Regulator of Wound Angiogenesis
por: Michalczyk, Elizabeth R., et al.
Publicado: (2018)

Changes in Plasma VEGF and PEDF Levels in Patients with Central Serous Chorioretinopathy
por: Chrząszcz, Michał, et al.
Publicado: (2021)

Pigment Epithelium-Derived Factor (PEDF) mediates cartilage matrix loss in an age-dependent manner under inflammatory conditions
por: Nakamura, Daisy S., et al.
Publicado: (2017)

PEDF-Mediated Mitophagy Triggers the Visual Cycle by Enhancing Mitochondrial Functions in a H(2)O(2)-Injured Rat Model
por: Kim, Jae Yeon, et al.
Publicado: (2021)

Pigment Epithelium-Derived Factor (PEDF) Inhibits Wnt/β-catenin Signaling in the Liver
por: Protiva, Petr, et al.
Publicado: (2015)

Cell and Molecular Biology Underpinning the Effects of PEDF on Cancers in General and Osteosarcoma in Particular
por: Chandolu, Vijay, et al.
Publicado: (2012)

Levels of PEDF in Pleural Effusions from Lung Adenocarcinoma and Benign Disease Patients
por: Sánchez-Otero, Nuria, et al.
Publicado: (2013)

Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF
por: Cheng, Guo, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_imj8oummo8d4vb83eseomlukgf