Peripheral nerve injury increases contribution of L-type calcium channels to synaptic transmission in spinal lamina II: Role of α2δ–1 subunits

BACKGROUND: Following peripheral nerve chronic constriction injury, the accumulation of the α2δ–1 auxiliary subunit of voltage-gated Ca(2+) channels in primary afferent terminals contributes to the onset of neuropathic pain. Overexpression of α2δ–1 in Xenopus oocytes increases the opening properties...

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Detalles Bibliográficos
Autores principales: Alles, Sascha RA, Garcia, Esperanza, Balasubramanyan, Sridhar, Jones, Karen, Tyson, John R, Joy, Twinkle, Snutch, Terrance P, Smith, Peter A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882044/
https://www.ncbi.nlm.nih.gov/pubmed/29580153
http://dx.doi.org/10.1177/1744806918765806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882044/
https://www.ncbi.nlm.nih.gov/pubmed/29580153
http://dx.doi.org/10.1177/1744806918765806

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