Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues

The malaria-causing blood stage of Plasmodium falciparum requires extracellular pantothenate for proliferation. The parasite converts pantothenate into coenzyme A (CoA) via five enzymes, the first being a pantothenate kinase (PfPanK). Multiple antiplasmodial pantothenate analogues, including pantoth...

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Detalles Bibliográficos
Autores principales: Tjhin, Erick T., Spry, Christina, Sewell, Alan L., Hoegl, Annabelle, Barnard, Leanne, Sexton, Anna E., Siddiqui, Ghizal, Howieson, Vanessa M., Maier, Alexander G., Creek, Darren J., Strauss, Erick, Marquez, Rodolfo, Auclair, Karine, Saliba, Kevin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882169/
https://www.ncbi.nlm.nih.gov/pubmed/29614109
http://dx.doi.org/10.1371/journal.ppat.1006918

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882169/
https://www.ncbi.nlm.nih.gov/pubmed/29614109
http://dx.doi.org/10.1371/journal.ppat.1006918

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