Deletion of transketolase triggers a stringent metabolic response in promastigotes and loss of virulence in amastigotes of Leishmania mexicana

Transketolase (TKT) is part of the non-oxidative branch of the pentose phosphate pathway (PPP). Here we describe the impact of removing this enzyme from the pathogenic protozoan Leishmania mexicana. Whereas the deletion had no obvious effect on cultured promastigote forms of the parasite, the Δtkt c...

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Detalles Bibliográficos
Autores principales: Kovářová, Julie, Pountain, Andrew W., Wildridge, David, Weidt, Stefan, Bringaud, Frédéric, Burchmore, Richard J. S., Achcar, Fiona, Barrett, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882173/
https://www.ncbi.nlm.nih.gov/pubmed/29554142
http://dx.doi.org/10.1371/journal.ppat.1006953

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882173/
https://www.ncbi.nlm.nih.gov/pubmed/29554142
http://dx.doi.org/10.1371/journal.ppat.1006953

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