Exploiting mitochondrial and metabolic homeostasis as a vulnerability in NF1 deficient cells

Neurofibromatosis type 1 is a disease caused by mutation of neurofibromin 1 (NF1), loss of which results in hyperactive Ras signaling and a concomitant increase in cell proliferation and survival. Patients with neurofibromatosis type 1 frequently develop tumors such as plexiform neurofibromas and ma...

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Detalles Bibliográficos
Autores principales: Allaway, Robert J., Wood, Matthew D., Downey, Sondra L., Bouley, Stephanie J., Traphagen, Nicole A., Wells, Jason D., Batra, Jaya, Melancon, Sir Norman, Ringelberg, Carol, Seibel, William, Ratner, Nancy, Sanchez, Yolanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882303/
https://www.ncbi.nlm.nih.gov/pubmed/29662612
http://dx.doi.org/10.18632/oncotarget.19335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882303/
https://www.ncbi.nlm.nih.gov/pubmed/29662612
http://dx.doi.org/10.18632/oncotarget.19335

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