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Conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid
Peptide mediated gain-of-toxic function is central to pathology in Alzheimer’s, Parkinson’s and diabetes. In each system, self-assembly into oligomers is observed and can also result in poration of artificial membranes. Structural requirements for poration and the relationship of structure to cytoto...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882805/ https://www.ncbi.nlm.nih.gov/pubmed/29615609 http://dx.doi.org/10.1038/s41467-018-03651-9 |