Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms

Incomplete delivery to the target cells is an obstacle for successful gene therapy approaches. Here we show unexpected effects of incomplete targeting, by demonstrating how heterogeneous inhibition of a growth promoting signaling pathway promotes tissue hyperplasia. We studied the function of the ly...

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Detalles Bibliográficos
Autores principales: Zhang, Yan, Ulvmar, Maria H., Stanczuk, Lukas, Martinez-Corral, Ines, Frye, Maike, Alitalo, Kari, Mäkinen, Taija
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882855/
https://www.ncbi.nlm.nih.gov/pubmed/29615616
http://dx.doi.org/10.1038/s41467-018-03692-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882855/
https://www.ncbi.nlm.nih.gov/pubmed/29615616
http://dx.doi.org/10.1038/s41467-018-03692-0

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