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Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms

Incomplete delivery to the target cells is an obstacle for successful gene therapy approaches. Here we show unexpected effects of incomplete targeting, by demonstrating how heterogeneous inhibition of a growth promoting signaling pathway promotes tissue hyperplasia. We studied the function of the ly...

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Detalles Bibliográficos
Autores principales:	Zhang, Yan, Ulvmar, Maria H., Stanczuk, Lukas, Martinez-Corral, Ines, Frye, Maike, Alitalo, Kari, Mäkinen, Taija
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882855/ https://www.ncbi.nlm.nih.gov/pubmed/29615616 http://dx.doi.org/10.1038/s41467-018-03692-0

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