Longterm Reversal of Severe Visual Loss by Mitochondrial Gene Transfer in a Mouse Model of Leber Hereditary Optic Neuropathy

In many human disorders mitochondrial dysfunction is central to degeneration of retinal ganglion cells. As these cells do not regenerate, vision is irreversibly lost. Here we show reversal of visual dysfunction by a mitochondrially targeted adeno associated virus in transgenic mice harboring a G1177...

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Detalles Bibliográficos
Autores principales: Yu, Hong, Porciatti, Vittorio, Lewin, Alfred, Hauswirth, William, Guy, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882860/
https://www.ncbi.nlm.nih.gov/pubmed/29615737
http://dx.doi.org/10.1038/s41598-018-23836-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882860/
https://www.ncbi.nlm.nih.gov/pubmed/29615737
http://dx.doi.org/10.1038/s41598-018-23836-y

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