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Overexpression of ß-Arrestin1 in the Rostral Ventrolateral Medulla Downregulates Angiotensin Receptor and Lowers Blood Pressure in Hypertension
Background: Hypertension is characterized by sympathetic overactivity, which is associated with an enhancement in angiotensin receptor type I (AT1R) in the rostral ventrolateral medulla (RVLM). β-arrestin1, a canonical scaffold protein, has been suggested to show a negative effect on G protein-coupl...
Autores principales: | Sun, Jia-Cen, Liu, Bing, Zhang, Ru-Wen, Jiao, Pei-Lei, Tan, Xing, Wang, Yang-Kai, Wang, Wei-Zhong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882868/ https://www.ncbi.nlm.nih.gov/pubmed/29643817 http://dx.doi.org/10.3389/fphys.2018.00297 |
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