Small Molecules Attenuate the Interplay between Conformational Fluctuations, Early Oligomerization and Amyloidosis of Alpha Synuclein

Aggregation of alpha synuclein has strong implications in Parkinson’s disease. The heterogeneity of folding/aggregation landscape and transient nature of the early intermediates result in difficulty in developing a successful therapeutic intervention. Here we used fluorescence measurements at ensemb...

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Detalles Bibliográficos
Autores principales: Ghosh, Sumanta, Kundu, Amrita, Chattopadhyay, Krishnananda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882917/
https://www.ncbi.nlm.nih.gov/pubmed/29615762
http://dx.doi.org/10.1038/s41598-018-23718-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882917/
https://www.ncbi.nlm.nih.gov/pubmed/29615762
http://dx.doi.org/10.1038/s41598-018-23718-3

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