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Lentiviral vector delivery of short hairpin RNA to NgR1 promotes nerve regeneration and locomotor recovery in injured rat spinal cord

Nogo receptor 1 (NgR1) is a high-affinity receptor of myelin-associated inhibitors (MAIs), and suppresses neurogenesis. Lentiviral vector are commonly used to alter the expression of targeted genes. However, little is known about the potential function of lentiviral vector harboring NgR1 shRNA (LV-N...

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Detalles Bibliográficos
Autores principales: Zhao, Xiaoyang, Peng, Zhiming, Long, Lingli, Chen, Ningning, Zheng, Haichong, Deng, David Y. B., Wan, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882972/
https://www.ncbi.nlm.nih.gov/pubmed/29615686
http://dx.doi.org/10.1038/s41598-018-23751-2