Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply

Lipoprotein lipase (LPL) mediates hydrolysis of triglycerides (TGs) to supply free fatty acids (FFAs) to tissues. Here, we show that LPL activity is also required for hematopoietic stem progenitor cell (HSPC) maintenance. Knockout of Lpl or its obligatory cofactor Apoc2 results in significantly redu...

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Detalles Bibliográficos
Autores principales: Liu, Chao, Han, Tianxu, Stachura, David L., Wang, Huawei, Vaisman, Boris L., Kim, Jungsu, Klemke, Richard L., Remaley, Alan T., Rana, Tariq M., Traver, David, Miller, Yury I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882990/
https://www.ncbi.nlm.nih.gov/pubmed/29615667
http://dx.doi.org/10.1038/s41467-018-03775-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882990/
https://www.ncbi.nlm.nih.gov/pubmed/29615667
http://dx.doi.org/10.1038/s41467-018-03775-y

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