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Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations

Melanoma, a skin cancer associated with high mortality rates, is highly radio- and chemotherapy resistant but can also be very immunogenic. These circumstances have led to a recent surge in research into therapies aiming to boost anti-tumor immune responses in cancer patients. Among these immunother...

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Detalles Bibliográficos
Autores principales: Seidel, Judith A., Otsuka, Atsushi, Kabashima, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883082/
https://www.ncbi.nlm.nih.gov/pubmed/29644214
http://dx.doi.org/10.3389/fonc.2018.00086