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Loss of XBP1 accelerates age-related decline in retinal function and neurodegeneration

BACKGROUND: Aging is the strongest risk factor for neurodegenerative diseases and extended age results in neuronal degeneration and functional decline in the visual system. Among many contributing factors to age-related deterioration of neurons is an insufficient activation of the Unfolded Protein R...

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Detalles Bibliográficos
Autores principales:	McLaughlin, Todd, Falkowski, Marek, Park, Jae Whan, Keegan, Stephen, Elliott, Michael, Wang, Joshua J., Zhang, Sarah X.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883257/ https://www.ncbi.nlm.nih.gov/pubmed/29615095 http://dx.doi.org/10.1186/s13024-018-0250-z

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