27-Hydroxycholesterol increases α-synuclein protein levels through proteasomal inhibition in human dopaminergic neurons

BACKGROUND: Accumulation of the α-synuclein (α-syn) protein is a hallmark of a group of brain disorders collectively known as synucleinopathies. The mechanisms responsible for α-syn accumulation are not well understood. Several studies suggest a link between synucleinopathies and the cholesterol met...

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Detalles Bibliográficos
Autores principales: Schommer, Jared, Marwarha, Gurdeep, Schommer, Trevor, Flick, Travis, Lund, Jonah, Ghribi, Othman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883307/
https://www.ncbi.nlm.nih.gov/pubmed/29614969
http://dx.doi.org/10.1186/s12868-018-0420-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883307/
https://www.ncbi.nlm.nih.gov/pubmed/29614969
http://dx.doi.org/10.1186/s12868-018-0420-5

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