Hypertrophic cardiomyopathy mutation R58Q in the myosin regulatory light chain perturbs thick filament-based regulation in cardiac muscle

Hypertrophic cardiomyopathy (HCM) is frequently linked to mutations in the protein components of the myosin-containing thick filaments leading to contractile dysfunction and ultimately heart failure. However, the molecular structure-function relationships that underlie these pathological effects rem...

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Detalles Bibliográficos
Autores principales: Kampourakis, Thomas, Ponnam, Saraswathi, Irving, Malcolm
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883317/
https://www.ncbi.nlm.nih.gov/pubmed/29452157
http://dx.doi.org/10.1016/j.yjmcc.2018.02.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883317/
https://www.ncbi.nlm.nih.gov/pubmed/29452157
http://dx.doi.org/10.1016/j.yjmcc.2018.02.009

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