Cargando…
New endoperoxides highly active in vivo and in vitro against artemisinin-resistant Plasmodium falciparum
BACKGROUND: The emergence and spread of Plasmodium falciparum resistance to artemisinin-based combination therapy in Southeast Asia prompted the need to develop new endoperoxide-type drugs. METHODS: A chemically diverse library of endoperoxides was designed and synthesized. The compounds were screen...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883364/ https://www.ncbi.nlm.nih.gov/pubmed/29615130 http://dx.doi.org/10.1186/s12936-018-2281-x |