Modeling and rescue of defective blood–brain barrier function of induced brain microvascular endothelial cells from childhood cerebral adrenoleukodystrophy patients

BACKGROUND: X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ABCD1 gene. 40% of X-ALD patients will convert to the deadly childhood cerebral form (ccALD) characterized by increased permeability of the brain endothelium that constitutes the blood–brain barrier (BBB). Mutation infor...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Catherine A. A., Seo, Hannah S., Armien, Anibal G., Bates, Frank S., Tolar, Jakub, Azarin, Samira M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883398/
https://www.ncbi.nlm.nih.gov/pubmed/29615068
http://dx.doi.org/10.1186/s12987-018-0094-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883398/
https://www.ncbi.nlm.nih.gov/pubmed/29615068
http://dx.doi.org/10.1186/s12987-018-0094-5

Ejemplares similares