Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression

The amyloid cascade hypothesis posits that the initiating event in Alzheimer’s disease (AD) is the aggregation and deposition of the β-amyloid (Aβ) peptide, which is a proteolytic cleavage product of the amyloid precursor protein (APP). Mounting evidence suggests that the formation and spread of pri...

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Detalles Bibliográficos
Autores principales: Ruiz-Riquelme, Alejandro, Lau, Heather H. C., Stuart, Erica, Goczi, Adrienn N., Wang, Zhilan, Schmitt-Ulms, Gerold, Watts, Joel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883524/
https://www.ncbi.nlm.nih.gov/pubmed/29615128
http://dx.doi.org/10.1186/s40478-018-0529-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883524/
https://www.ncbi.nlm.nih.gov/pubmed/29615128
http://dx.doi.org/10.1186/s40478-018-0529-x

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