Cargando…

Differentiation of human pluripotent stem cells into two distinct NKX6.1 populations of pancreatic progenitors

BACKGROUND: The expression of a specific combination of transcription factors (TFs) in the multipotent progenitor cells (MPCs) is critical for determining pancreatic cell fate. NKX6.1 expression in PDX1(+) MPCs is required for functional β cell generation. We have recently demonstrated the generatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aigha, Idil I., Memon, Bushra, Elsayed, Ahmed K., Abdelalim, Essam M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883581/ https://www.ncbi.nlm.nih.gov/pubmed/29615106 http://dx.doi.org/10.1186/s13287-018-0834-0

Ejemplares similares

Enhanced differentiation of human pluripotent stem cells into pancreatic progenitors co-expressing PDX1 and NKX6.1
por: Memon, Bushra, et al.
Publicado: (2018)

Correction to: Enhanced differentiation of human pluripotent stem cells into pancreatic progenitors co-expressing PDX1 and NKX6.1
por: Memon, Bushra, et al.
Publicado: (2018)

NKX6.1 transcription factor: a crucial regulator of pancreatic β cell development, identity, and proliferation
por: Aigha, Idil I., et al.
Publicado: (2020)

p53 Inhibition in Pancreatic Progenitors Enhances the Differentiation of Human Pluripotent Stem Cells into Pancreatic β-Cells
por: Aigha, Idil I., et al.
Publicado: (2023)

Stem Cell Therapy for Diabetes: Beta Cells versus Pancreatic Progenitors
por: Memon, Bushra, et al.
Publicado: (2020)

Toward Precision Medicine with Human Pluripotent Stem Cells for Diabetes
por: Memon, Bushra, et al.
Publicado: (2022)

Maturation of pluripotent stem cell derived cardiomyocytes: The new challenge
por: Aigha, Idil, et al.
Publicado: (2016)

Efficient Generation of NKX6-1(+) Pancreatic Progenitors from Multiple Human Pluripotent Stem Cell Lines
por: Nostro, M. Cristina, et al.
Publicado: (2015)

Controlled clustering enhances PDX1 and NKX6.1 expression in pancreatic endoderm cells derived from pluripotent stem cells
por: Tran, Raymond, et al.
Publicado: (2020)

Control of Astrocyte Progenitor Specification, Migration and Maturation by Nkx6.1 Homeodomain Transcription Factor
por: Zhao, Xiaofeng, et al.
Publicado: (2014)

Transcriptional Regulation of Notch1 Expression by Nkx6.1 in Neural Stem/Progenitor Cells during Ventral Spinal Cord Development
por: Li, Ying, et al.
Publicado: (2016)

Progenitor potential of nkx6.1-expressing cells throughout zebrafish life and during beta cell regeneration
por: Ghaye, Aurélie P., et al.
Publicado: (2015)

ACE2 function in the pancreatic islet: Implications for relationship between SARS‐CoV‐2 and diabetes
por: Memon, Bushra, et al.
Publicado: (2021)

NKX6.1 Represses Tumorigenesis, Metastasis, and Chemoresistance in Colorectal Cancer
por: Chung, Hsin-Hua, et al.
Publicado: (2020)

Directed differentiation of human iPSC into insulin producing cells is improved by induced expression of PDX1 and NKX6.1 factors in IPC progenitors
por: Walczak, Maciej P., et al.
Publicado: (2016)

Keratinocytes Derived from Patient-Specific Induced Pluripotent Stem Cells Recapitulate the Genetic Signature of Psoriasis Disease
por: Ali, Gowher, et al.
Publicado: (2020)

Directed differentiation of human pluripotent stem cells into epidermal keratinocyte-like cells
por: Ali, Gowher, et al.
Publicado: (2022)

Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell Identity
por: Schaffer, Ashleigh E., et al.
Publicado: (2013)

Silymarin Induces Expression of Pancreatic Nkx6.1 Transcription Factor and β-Cells Neogenesis in a Pancreatectomy Model
por: Soto, Claudia, et al.
Publicado: (2014)

In vitro quantitative and relative gene expression analysis of pancreatic transcription factors Pdx‐1, Ngn‐3, Isl‐1, Pax‐4, Pax‐6 and Nkx‐6.1 in trans‐differentiated human hepatic progenitors
por: Vishwakarma, Sandeep Kumar, et al.
Publicado: (2014)

Insulin resistance in diabetes: The promise of using induced pluripotent stem cell technology
por: Elsayed, Ahmed K, et al.
Publicado: (2021)

iPSC-Derived Pancreatic Progenitors Lacking FOXA2 Reveal Alterations in miRNA Expression Targeting Key Pancreatic Genes
por: Aldous, Noura, et al.
Publicado: (2023)

Comment on Carrasco et al. Spatial Environment Affects HNF4A Mutation-Specific Proteome Signatures and Cellular Morphology in hiPSC-Derived β-Like Cells. Diabetes 2022;71:862–869
por: Memon, Bushra, et al.
Publicado: (2023)

NKX6.1 functions as a metastatic suppressor through epigenetic regulation of the epithelial–mesenchymal transition
por: Li, H-J, et al.
Publicado: (2016)

Micro-RNA-124-5p promotes insulin producing cell differentiation through regulating transcriptional factor NKX6.1
por: Zhang, Xianjun, et al.
Publicado: (2022)

Isolation of mineralizing Nestin+ Nkx6.1+ vascular muscular cells from the adult human spinal cord
por: Mamaeva, Daria, et al.
Publicado: (2011)

Deficiency of transcription factor Nkx6.1 does not prevent insulin secretion in INS-1E cells
por: Pavluch, Vojtěch, et al.
Publicado: (2023)

NKX6.3 controls gastric differentiation and tumorigenesis
por: Yoon, Jung Hwan, et al.
Publicado: (2015)

Nkx6.1 decline accompanies mitochondrial DNA reduction but subtle nucleoid size decrease in pancreatic islet β-cells of diabetic Goto Kakizaki rats
por: Špaček, Tomáš, et al.
Publicado: (2017)

Genome-wide differential expression profiling of long non-coding RNAs in FOXA2 knockout iPSC-derived pancreatic cells
por: Elsayed, Ahmed K., et al.
Publicado: (2023)

Scalable Generation of Mesenchymal Stem Cells and Adipocytes from Human Pluripotent Stem Cells
por: Karam, Manale, et al.
Publicado: (2020)

Differentiation of beta-like cells from human induced pluripotent stem cell-derived pancreatic progenitor organoids
por: Pedraza-Arevalo, Sergio, et al.
Publicado: (2022)

Photo-click hydrogels for 3D in situ differentiation of pancreatic progenitors from induced pluripotent stem cells
por: Arkenberg, Matthew R., et al.
Publicado: (2023)

Photo-click hydrogels for 3D in situ differentiation of pancreatic progenitors from induced pluripotent stem cells
por: Arkenberg, Matthew R., et al.
Publicado: (2023)

Generation of pancreatic progenitors from human pluripotent stem cells by small molecules
por: Jiang, Yuqian, et al.
Publicado: (2021)

Increased NKX6.1 expression and decreased ARX expression in alpha cells accompany reduced beta-cell volume in human subjects
por: Fujita, Yukari, et al.
Publicado: (2021)

Human Pluripotent Stem Cell Differentiation into Functional Epicardial Progenitor Cells
por: Guadix, Juan Antonio, et al.
Publicado: (2017)

Metabolomic profiling of human pluripotent stem cell differentiation into lung progenitors
por: Leibel, Sandra L., et al.
Publicado: (2022)

Netrin-1/DCC Signaling Differentially Regulates the Migration of Pax7, Nkx6.1, Irx2, Otp, and Otx2 Cell Populations in the Developing Interpeduncular Nucleus
por: García-Guillén, Isabel M., et al.
Publicado: (2020)

Increased frequency of β cells with abnormal NKX6.1 expression in type 2 diabetes but not in subjects with higher risk for type 2 diabetes
por: Liu, Tengli, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_fb7kqmvsk8cgsa0uvagjmnrs2v