Designing interactions by control of protein–ligand complex conformation: tuning arginine–arene interaction geometry for enhanced electrostatic protein–ligand interactions

We investigated galectin-3 binding to 3-benzamido-2-O-sulfo-galactoside and -thiodigalactoside ligands using a combination of site-specific mutagenesis, X-ray crystallography, computational approaches, and binding thermodynamics measurements. The results reveal a conformational variability in a surf...

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Detalles Bibliográficos
Autores principales: Noresson, A.-L., Aurelius, O., Öberg, C. T., Engström, O., Sundin, A. P., Håkansson, M., Stenström, O., Akke, M., Logan, D. T., Leffler, H., Nilsson, U. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883865/
https://www.ncbi.nlm.nih.gov/pubmed/29675148
http://dx.doi.org/10.1039/c7sc04749e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883865/
https://www.ncbi.nlm.nih.gov/pubmed/29675148
http://dx.doi.org/10.1039/c7sc04749e

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