Engineering metabolic pathways in Amycolatopsis japonicum for the optimization of the precursor supply for heterologous brasilicardin congeners production

The isoprenoid brasilicardin A is a promising immunosuppressant compound with a unique mode of action, high potency and reduced toxicity compared to today's standard drugs. However, production of brasilicardin has been hampered since the producer strain Nocardia terpenica IFM0406 synthesizes br...

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Detalles Bibliográficos
Autores principales: Schwarz, Paul N., Roller, Luisa, Kulik, Andreas, Wohlleben, Wolfgang, Stegmann, Evi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884276/
https://www.ncbi.nlm.nih.gov/pubmed/29911199
http://dx.doi.org/10.1016/j.synbio.2017.12.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884276/
https://www.ncbi.nlm.nih.gov/pubmed/29911199
http://dx.doi.org/10.1016/j.synbio.2017.12.005

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