In Vivo 6-([(18)F]Fluoroacetamido)-1-hexanoicanilide PET Imaging of Altered Histone Deacetylase Activity in Chemotherapy-Induced Neurotoxicity

BACKGROUND: Histone deacetylases (HDACs) regulate gene expression by changing histone deacetylation status. Neurotoxicity is one of the major side effects of cisplatin, which reacts with deoxyribonucleic acid (DNA) and has excellent antitumor effects. Suberoylanilide hydroxamic acid (SAHA) is an HDA...

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Detalles Bibliográficos
Autores principales: Fukumitsu, Nobuyoshi, Yeh, Skye Hsin-Hsien, Flores II, Leo Garcia, Mukhopadhyay, Uday, Young, Daniel, Ogawa, Kazuma, Jeong, Hwan-Jeong, Tong, William, Gelovani, Juri G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884410/
https://www.ncbi.nlm.nih.gov/pubmed/29755299
http://dx.doi.org/10.1155/2018/3612027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884410/
https://www.ncbi.nlm.nih.gov/pubmed/29755299
http://dx.doi.org/10.1155/2018/3612027

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