Toxicological and pharmacological assessment of AGEN1884, a novel human IgG1 anti-CTLA-4 antibody

CTLA-4 and CD28 exemplify a co-inhibitory and co-stimulatory signaling axis that dynamically sculpts the interaction of antigen-specific T cells with antigen-presenting cells. Anti-CTLA-4 antibodies enhance tumor-specific immunity through a variety of mechanisms including: blockade of CD80 or CD86 b...

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Detalles Bibliográficos
Autores principales: Gombos, Randi B., Gonzalez, Ana, Manrique, Mariana, Chand, Dhan, Savitsky, David, Morin, Benjamin, Breous-Nystrom, Ekaterina, Dupont, Christopher, Ward, Rebecca A., Mundt, Cornelia, Duckless, Benjamin, Tang, Hao, Findeis, Mark A., Schuster, Andrea, Waight, Jeremy D., Underwood, Dennis, Clarke, Christopher, Ritter, Gerd, Merghoub, Taha, Schaer, David, Wolchok, Jedd D., van Dijk, Marc, Buell, Jennifer S., Cuillerot, Jean-Marie, Stein, Robert, Drouin, Elise E., Wilson, Nicholas S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884502/
https://www.ncbi.nlm.nih.gov/pubmed/29617360
http://dx.doi.org/10.1371/journal.pone.0191926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884502/
https://www.ncbi.nlm.nih.gov/pubmed/29617360
http://dx.doi.org/10.1371/journal.pone.0191926

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