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A high content, high throughput cellular thermal stability assay for measuring drug-target engagement in living cells
Determining and understanding drug target engagement is critical for drug discovery. This can be challenging within living cells as selective readouts are often unavailable. Here we describe a novel method for measuring target engagement in living cells based on the principle of altered protein ther...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884524/ https://www.ncbi.nlm.nih.gov/pubmed/29617433 http://dx.doi.org/10.1371/journal.pone.0195050 |