A low-barrier hydrogen bond mediates antibiotic resistance in a noncanonical catalytic triad

One group of enzymes that confer resistance to aminoglycoside antibiotics through covalent modification belongs to the GCN5-related N-acetyltransferase (GNAT) superfamily. We show how a unique GNAT subfamily member uses a previously unidentified noncanonical catalytic triad, consisting of a glutamic...

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Detalles Bibliográficos
Autores principales: Kumar, Prashasti, Serpersu, Engin H., Cuneo, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884680/
https://www.ncbi.nlm.nih.gov/pubmed/29632894
http://dx.doi.org/10.1126/sciadv.aas8667

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884680/
https://www.ncbi.nlm.nih.gov/pubmed/29632894
http://dx.doi.org/10.1126/sciadv.aas8667

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