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A low-barrier hydrogen bond mediates antibiotic resistance in a noncanonical catalytic triad

One group of enzymes that confer resistance to aminoglycoside antibiotics through covalent modification belongs to the GCN5-related N-acetyltransferase (GNAT) superfamily. We show how a unique GNAT subfamily member uses a previously unidentified noncanonical catalytic triad, consisting of a glutamic...

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Detalles Bibliográficos
Autores principales:	Kumar, Prashasti, Serpersu, Engin H., Cuneo, Matthew J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884680/ https://www.ncbi.nlm.nih.gov/pubmed/29632894 http://dx.doi.org/10.1126/sciadv.aas8667

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