Cargando…

A low-barrier hydrogen bond mediates antibiotic resistance in a noncanonical catalytic triad

One group of enzymes that confer resistance to aminoglycoside antibiotics through covalent modification belongs to the GCN5-related N-acetyltransferase (GNAT) superfamily. We show how a unique GNAT subfamily member uses a previously unidentified noncanonical catalytic triad, consisting of a glutamic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kumar, Prashasti, Serpersu, Engin H., Cuneo, Matthew J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884680/ https://www.ncbi.nlm.nih.gov/pubmed/29632894 http://dx.doi.org/10.1126/sciadv.aas8667

Ejemplares similares

Direct evidence of a low barrier hydrogen bond in the catalytic triad of a Serine protease
por: Agback, Peter, et al.
Publicado: (2018)

An N⋯H⋯N low-barrier hydrogen bond preorganizes the catalytic site of aspartate aminotransferase to facilitate the second half-reaction
por: Drago, Victoria N., et al.
Publicado: (2022)

Low Barrier Hydrogen Bonds: Getting Close, but Not Sharing...
por: Klinman, Judith P.
Publicado: (2015)

Absorption wavelength along chromophore low-barrier hydrogen bonds
por: Tsujimura, Masaki, et al.
Publicado: (2022)

Selective hydrogenation via precise hydrogen bond interactions on catalytic scaffolds
por: Shi, Song, et al.
Publicado: (2023)

A Noncanonical Tryptophan Analogue Reveals an Active Site Hydrogen Bond Controlling Ferryl Reactivity in a Heme Peroxidase
por: Ortmayer, Mary, et al.
Publicado: (2021)

Transient kinetics of aminoglycoside phosphotransferase(3′)-IIIa reveals a potential drug target in the antibiotic resistance mechanism
por: Lallemand, Perrine, et al.
Publicado: (2012)

Expanding the Catalytic Triad in Epoxide Hydrolases and Related Enzymes
por: Amrein, Beat A., et al.
Publicado: (2015)

The Nϵ‐Rule for Serine, but Not Cysteine Catalytic Triads
por: Czapinska, Honorata, et al.
Publicado: (2022)

Contribution of a Low-Barrier Hydrogen Bond to Catalysis Is Not Significant in Ketosteroid Isomerase
por: Jang, Do Soo, et al.
Publicado: (2015)

Low-Barrier Hydrogen Bond in Fujikurin A–D: A Computational Study
por: Tanaka, Hikaru, et al.
Publicado: (2022)

Metal–Ligand Cooperation Facilitates Bond Activation and Catalytic Hydrogenation with Zinc Pincer Complexes
por: Rauch, Michael, et al.
Publicado: (2020)

Histidine-Triad Hydrolases Provide Resistance to Peptide-Nucleotide Antibiotics
por: Yagmurov, Eldar, et al.
Publicado: (2020)

Three critical hydrogen bonds determine the catalytic activity of the Diels–Alderase ribozyme
por: Kraut, Stefanie, et al.
Publicado: (2012)

Dynamic Allostery Modulates Catalytic Activity by Modifying the Hydrogen Bonding Network in the Catalytic Site of Human Pin1
por: Wang, Jing, et al.
Publicado: (2017)

Design of activated serine-containing catalytic triads with atomic level accuracy
por: Rajagopalan, Sridharan, et al.
Publicado: (2014)

Remote Control of Anion–π Catalysis on Fullerene‐Centered Catalytic Triads
por: López‐Andarias, Javier, et al.
Publicado: (2018)

Transmembrane anion transport mediated by halogen bonding and hydrogen bonding triazole anionophores
por: Bickerton, Laura E., et al.
Publicado: (2020)

Noncanonical Mismatch Repair Protein NucS Modulates the Emergence of Antibiotic Resistance in Mycobacterium abscessus
por: Fressatti Cardoso, Rosilene, et al.
Publicado: (2022)

Room temperature catalytic carbon–hydrogen bond alumination of unactivated arenes: mechanism and selectivity
por: Hooper, Thomas N., et al.
Publicado: (2018)

Catalytic Effect of Hydrogen Bond on Oxhydryl Dehydrogenation in Methanol Steam Reforming on Ni(111)
por: Ke, Changming, et al.
Publicado: (2020)

Intercalating lithium into the lattice of silver nanoparticles boosts catalytic hydrogenation of carbon–oxygen bonds
por: Duan, Xin-ping, et al.
Publicado: (2021)

Consequences of the loss of catalytic triads in chloroplast CLPPR protease core complexes in vivo
por: Liao, Jui‐Yun Rei, et al.
Publicado: (2018)

Noncanonical Wnt Signaling in the Integrity of the Blood-Testis Barrier and Sperm Release
por: Rey, Rodolfo A
Publicado: (2021)

Vibrational analysis on the revised potential energy curve of the low-barrier hydrogen bond in photoactive yellow protein
por: Kanematsu, Yusuke, et al.
Publicado: (2015)

Hydrogen Bonding with Hydridic Hydrogen–Experimental Low-Temperature IR and Computational Study: Is a Revised Definition of Hydrogen Bonding Appropriate?
por: Civiš, Svatopluk, et al.
Publicado: (2023)

Amide Spectral Fingerprints are Hydrogen Bonding-Mediated
por: Gómez, Sara, et al.
Publicado: (2022)

Extreme Catalytic Power of Ketosteroid Isomerase Related to the Reversal of Proton Dislocations in Hydrogen-Bond Network
por: Kędzierski, Paweł, et al.
Publicado: (2020)

Hydrogen‐Bond‐Modulated Nucleofugality of Se(III) Species to Enable Photoredox‐Catalytic Semipinacol Manifolds
por: Park, Sooyoung, et al.
Publicado: (2022)

The involvement of the aspartate triad of the active center in all catalytic activities of multisubunit RNA polymerase
por: Sosunov, Vasily, et al.
Publicado: (2005)

Identification of the Catalytic Triad of Family S46 Exopeptidases, Closely Related to Clan PA Endopeptidases
por: Suzuki, Yoshiyuki, et al.
Publicado: (2014)

DWV 3C Protease Uncovers the Diverse Catalytic Triad in Insect RNA Viruses
por: Yuan, Xuye, et al.
Publicado: (2022)

Investigation of the Catalytic Mechanism of a Soluble N-glycosyltransferase Allows Synthesis of N-glycans at Noncanonical Sequons
por: Hao, Zhiqiang, et al.
Publicado: (2023)

Catalytic Cleavage of the C-O Bond in 2,6-dimethoxyphenol Without External Hydrogen or Organic Solvent Using Catalytic Vanadium Metal
por: Yu, Peng, et al.
Publicado: (2020)

Noncanonical NF-κB in Cancer
por: Tegowski, Matthew, et al.
Publicado: (2018)

The hydrogen bond
por: Pimentel, George C, et al.
Publicado: (1960)

Hydrogen Bonds
por: Jabłoński, Mirosław
Publicado: (2023)

Noncanonical hamiltonian mechanics
por: Littlejohn, R G
Publicado: (1986)

Noncanonical Reactions of Flavoenzymes
por: Sobrado, Pablo
Publicado: (2012)

Boosting the electronic and catalytic properties of 2D semiconductors with supramolecular 2D hydrogen-bonded superlattices
por: Wang, Can, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_s94diq81fldvqfht4l0j9rn2st