CRISPR/Cas9-Mediated Gene Disruption Reveals the Importance of Zinc Metabolism for Fitness of the Dimorphic Fungal Pathogen Blastomyces dermatitidis

Blastomyces dermatitidis is a human fungal pathogen of the lung that can lead to disseminated disease in healthy and immunocompromised individuals. Genetic analysis of this fungus is hampered by the relative inefficiency of traditional recombination-based gene-targeting approaches. Here, we demonstr...

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Detalles Bibliográficos
Autores principales: Kujoth, Gregory C., Sullivan, Thomas D., Merkhofer, Richard, Lee, Taek-Jin, Wang, Huafeng, Brandhorst, Tristan, Wüthrich, Marcel, Klein, Bruce S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885028/
https://www.ncbi.nlm.nih.gov/pubmed/29615501
http://dx.doi.org/10.1128/mBio.00412-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885028/
https://www.ncbi.nlm.nih.gov/pubmed/29615501
http://dx.doi.org/10.1128/mBio.00412-18

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