In Vivo-Selected Compensatory Mutations Restore the Fitness Cost of Mosaic penA Alleles That Confer Ceftriaxone Resistance in Neisseria gonorrhoeae

Resistance to ceftriaxone in Neisseria gonorrhoeae is mainly conferred by mosaic penA alleles that encode penicillin-binding protein 2 (PBP2) variants with markedly lower rates of acylation by ceftriaxone. To assess the impact of these mosaic penA alleles on gonococcal fitness, we introduced the mos...

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Detalles Bibliográficos
Autores principales: Vincent, Leah R., Kerr, Samuel R., Tan, Yang, Tomberg, Joshua, Raterman, Erica L., Dunning Hotopp, Julie C., Unemo, Magnus, Nicholas, Robert A., Jerse, Ann E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885032/
https://www.ncbi.nlm.nih.gov/pubmed/29615507
http://dx.doi.org/10.1128/mBio.01905-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885032/
https://www.ncbi.nlm.nih.gov/pubmed/29615507
http://dx.doi.org/10.1128/mBio.01905-17

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