Age-related inflammatory bone marrow microenvironment induces ineffective erythropoiesis mimicking del(5q) MDS

Anemia is characteristic of myelodysplastic syndromes (MDS). The mechanisms of anemia in MDS are unclear. Using a mouse genetic approach, here we show that dual deficiency of mDia1 and miR-146a, encoded on chromosome 5q and commonly deleted in MDS (del(5q) MDS), causes an age-related anemia and inef...

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Detalles Bibliográficos
Autores principales: Mei, Y, Zhao, B, Basiorka, A A, Yang, J, Cao, L, Zhang, J, List, A, Ji, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886057/
https://www.ncbi.nlm.nih.gov/pubmed/29263441
http://dx.doi.org/10.1038/leu.2017.326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886057/
https://www.ncbi.nlm.nih.gov/pubmed/29263441
http://dx.doi.org/10.1038/leu.2017.326

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