Cargando…

Age-related inflammatory bone marrow microenvironment induces ineffective erythropoiesis mimicking del(5q) MDS

Anemia is characteristic of myelodysplastic syndromes (MDS). The mechanisms of anemia in MDS are unclear. Using a mouse genetic approach, here we show that dual deficiency of mDia1 and miR-146a, encoded on chromosome 5q and commonly deleted in MDS (del(5q) MDS), causes an age-related anemia and inef...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mei, Y, Zhao, B, Basiorka, A A, Yang, J, Cao, L, Zhang, J, List, A, Ji, P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886057/ https://www.ncbi.nlm.nih.gov/pubmed/29263441 http://dx.doi.org/10.1038/leu.2017.326

Ejemplares similares

Unraveling the Pathogenesis of MDS: The NLRP3 Inflammasome and Pyroptosis Drive the MDS Phenotype
por: Sallman, David A., et al.
Publicado: (2016)

SF3B1 deficiency impairs human erythropoiesis via activation of p53 pathway: implications for understanding of ineffective erythropoiesis in MDS
por: Huang, Yumin, et al.
Publicado: (2018)

Ineffective Erythropoiesis in β-Thalassemia
por: Ribeil, Jean-Antoine, et al.
Publicado: (2013)

Iron Loading and Overloading due to Ineffective Erythropoiesis
por: Tanno, Toshihiko, et al.
Publicado: (2010)

Improving Ineffective Erythropoiesis in Thalassemia: A Hope on the Horizon
por: Madan, Ujjwal, et al.
Publicado: (2021)

The Roles of Mitophagy and Autophagy in Ineffective Erythropoiesis in β-Thalassemia
por: Chaichompoo, Pornthip, et al.
Publicado: (2022)

β-Thalassemia: HiJAKing Ineffective Erythropoiesis and Iron Overload
por: Melchiori, Luca, et al.
Publicado: (2010)

Fetal hemoglobin rescues ineffective erythropoiesis in sickle cell disease
por: El Hoss, Sara, et al.
Publicado: (2020)

The transcriptomic landscape of normal and ineffective erythropoiesis at single-cell resolution
por: Doty, Raymond T., et al.
Publicado: (2023)

PP2A: The Achilles Heal in MDS with 5q Deletion
por: Sallman, David A., et al.
Publicado: (2014)

Ineffective Erythropoiesis in β-Thalassaemia: Key Steps and Therapeutic Options by Drugs
por: Longo, Filomena, et al.
Publicado: (2021)

PB1989: STUDY ON THE RELATIONSHIP BETWEEN MDS AND ABNORMAL LIPID METABOLISM IN BONE MARROW MICROENVIRONMENT
por: LI, Yuchun, et al.
Publicado: (2023)

The Correlation Between Ineffective Erythropoiesis Biomarkers and Development of Extramedullary Hematopoiesis in Patients with Thalassemia
por: Chansai, Siriyakorn, et al.
Publicado: (2022)

P1565: MITAPIVAT IMPROVES INEFFECTIVE ERYTHROPOIESIS AND REDUCES IRON OVERLOAD IN PATIENTS WITH PYRUVATE KINASE DEFICIENCY
por: van Beers, E. J., et al.
Publicado: (2022)

Multiple myeloma hinders erythropoiesis and causes anaemia owing to high levels of CCL3 in the bone marrow microenvironment
por: Liu, Lanting, et al.
Publicado: (2020)

Extracellular Vesicle Characteristics in β-thalassemia as Potential Biomarkers for Spleen Functional Status and Ineffective Erythropoiesis
por: Levin, Carina, et al.
Publicado: (2018)

Erythroferrone exacerbates iron overload and ineffective extramedullary erythropoiesis in a mouse model of β-thalassemia
por: Olivera, Joseph, et al.
Publicado: (2023)

The role of innate immunity in MDS pathogenesis
por: Sallman, David A., et al.
Publicado: (2019)

Bone Marrow Defects and Platelet Function: A Focus on MDS and CLL
por: Luu, Sarah, et al.
Publicado: (2018)

Targeting the Microenvironment in MDS: The Final Frontier
por: Teodorescu, Patric, et al.
Publicado: (2020)

Minihepcidins improve ineffective erythropoiesis and splenomegaly in a new mouse model of adult β-thalassemia major
por: Casu, Carla, et al.
Publicado: (2020)

A Proposed Concept for Defective Mitophagy Leading to Late Stage Ineffective Erythropoiesis in Pyruvate Kinase Deficiency
por: van Vuren, Annelies Johanna, et al.
Publicado: (2021)

A novel index to evaluate ineffective erythropoiesis in hematological diseases offers insights into sickle cell disease
por: Brewin, John, et al.
Publicado: (2021)

Ferroportin inhibitor vamifeport ameliorates ineffective erythropoiesis in a mouse model of b-thalassemia with blood transfusions
por: Kalleda, Natarajaswamy, et al.
Publicado: (2023)

Extended survival and reduced risk of AML progression in erythroid-responsive lenalidomide-treated patients with lower-risk del(5q) MDS
por: List, A F, et al.
Publicado: (2014)

Defective erythropoiesis in bone marrow is a mechanism of anemia in children with cancer.
por: Kim, MunHee, et al.
Publicado: (2002)

Erratum: Extended survival and reduced risk of AML progression in erythroid-responsive lenalidomide-treated patients with lower-risk del(5q) MDS
por: List, A F, et al.
Publicado: (2015)

Vitamin B5 and succinyl-CoA improve ineffective erythropoiesis in SF3B1 mutated myelodysplasia
por: Mian, Syed A, et al.
Publicado: (2023)

Heme-Oxygenases during Erythropoiesis in K562 and Human Bone Marrow Cells
por: Alves, Liliane R., et al.
Publicado: (2011)

Novel Therapeutic Approach to Improve Hematopoiesis in low risk MDS by Targeting MDSCs with The Fc-engineered CD33 Antibody BI 836858
por: Eksioglu, Erika A., et al.
Publicado: (2017)

Severe ineffective erythropoiesis discriminates prognosis in myelodysplastic syndromes: analysis based on 776 patients from a single centre
por: Huang, Huijun, et al.
Publicado: (2020)

Lenalidomide does not increase AML progression risk in RBC transfusion-dependent patients with Low- or Intermediate-1-risk MDS with del(5q): a comparative analysis
por: Kuendgen, A, et al.
Publicado: (2013)

Maturation-associated gene expression profiles during normal human bone marrow erythropoiesis
por: Mello, Fabiana V., et al.
Publicado: (2019)

Mesenchymal stem cells protect against malaria pathogenesis by reprogramming erythropoiesis in the bone marrow
por: Thakur, Reva S., et al.
Publicado: (2020)

G-CSF shifts erythropoiesis from bone marrow into spleen in the setting of systemic inflammation
por: Jing, Weiqiang, et al.
Publicado: (2020)

P699: MAGROLIMAB ALTERS THE TUMOR MICROENVIRONMENT TO IMPROVE BONE MARROW FUNCTIONS IN PATIENTS WITH ACUTE MYELOID LEUKEMIA (AML) AND HIGHER-RISK MYELODYSPLASTIC SYNDROMES (HR-MDS)
por: Johnson, Lisa, et al.
Publicado: (2023)

Germline ERCC excision repair 6 like 2 ( ERCC6L2 ) mutations lead to impaired erythropoiesis and reshaping of the bone marrow microenvironment
por: Armes, Hannah, et al.
Publicado: (2022)

Bone Marrow Microenvironment and Tumor Progression
por: Chantrain, Christophe F., et al.
Publicado: (2008)

In Vitro Study of Ineffective Erythropoiesis in Thalassemia: Diverse Intrinsic Pathophysiological Features of Erythroid Cells Derived from Various Thalassemia Syndromes
por: Kaewsakulthong, Woratree, et al.
Publicado: (2022)

Real-world Data From the Swiss Lenalidomide in MDS del(5q) (SLIM)—Registry Identify New Chances and Challenges in Lenalidomide Treatment of Patients With MDS del(5q)
por: Rüfer, Axel, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_sm032r185hg1031l9im67rpbrh