Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo

Loss of function mutations in progranulin (GRN) cause frontotemporal dementia, but how GRN haploinsufficiency causes neuronal dysfunction remains unclear. We previously showed that GRN is neurotrophic in vitro. Here, we used an in vivo axonal outgrowth system and observed a delayed recovery in GRN(−...

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Detalles Bibliográficos
Autores principales: Beel, Sander, Moisse, Matthieu, Damme, Markus, De Muynck, Louis, Robberecht, Wim, Van Den Bosch, Ludo, Saftig, Paul, Van Damme, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886064/
https://www.ncbi.nlm.nih.gov/pubmed/28453791
http://dx.doi.org/10.1093/hmg/ddx162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886064/
https://www.ncbi.nlm.nih.gov/pubmed/28453791
http://dx.doi.org/10.1093/hmg/ddx162

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